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Aug 2010 Herbal Nutrients Successful in Fighting Prostate Cancer

Summary:

Prostate cancer is one of the most common malignancies and the second leading cause of cancer-related death in men in the United States and in Western countries. Although prostate cancer medical treatments significantly reduce mortality rate among patients, chemotherapy using available anticancer drugs for advanced stage of prostate cancer still offers little survival benefit [1]. However, an increasing number of studies have recognized that natural herbal and phytochemical agents can be crucial in decreasing the morbidity and mortality associated with prostate cancer. For instance, the results in recent publication of Integrative Cancer Therapies journal indicate that the all-natural mixture of nutrients, studied at Columbia University, work together to provide long-lasting prostate protection [2].

Although the application of these herbal extracts may represent a new method in prostate cancer treatment, an ultimate strategy in fighting this disease should be broader, including wholesome diet, exercise and mental health.

 

Main text:

The all-natural compound ProstaCaid, studied at Columbia University, is a 33-ingredient comprehensive polyherbal compound with supplements of vitamin C, vitamin D3, zinc, selenium, quercitin, 3,3′-diinodolymethane (DIM), and lycopene. Herbal extracts included the extracts from turmeric root, saw palmetto berry, grape skin, pomegranate, pumpkin seed, pygeum bark, sarsaparilla root, green tea, and Japanese knotweed. As a result, this compound is rich in natural polyphenols which have previously demonstrated anticancer potential [3, 4, 5]. Besides herbal extracts the unique formula contained 3 medicinal mushrooms, each with known anticancer properties [6, 7, 8].

 

The results of the study have demonstrated that this specific mixture was able to stop abnormal cell growth and induce apoptosis (programmed cell death) in hormone sensitive prostate cancer cell lines, even at low concentrations. However, the most intriguing finding is that ProstaCaid was also efficient in case of hormone resistant tumors. According to the lead researcher, Dr. Aaron Katz, the effect on androgen-independent cancer cell lines is especially of importance as there is presently no curative therapy for hormone refractory prostate cancer. Furthermore, the potency of the compound is likely due to the synergistic effects of the multiple ingredients.

 

Because ProstaCaid is based on constituents that exhibit antiproliferative, antioxidant, and apoptotic activities. It may play an additional role in prostate cancer prevention. The authors are convinced that ongoing research about the effect of this natural compound on cancer will continue to show encouraging results, and additional studies are forthcoming. 

 

Eating foods composed of herbal ingredients exert beneficial effect on prognosis of cancer patients. However, other elements such as physical exercise and social support considerably help in overcoming cancer as well. We feel obliged to tell you that synergistic performance of all lifestyle elements represents a key point in cancer treatment.

 


By: Svetlana Obradovic and Luuk Simons

[1] Petrilak, D. P. (2005). The current role of chemotherapy in metastatic hormone-refractory prostate cancer. Urology 65 pp. 3-7.

http://www.goldjournal.net/article/S0090-4295%2805%2900366-3/abstract

 

[2] Yan, J., E. A. Katz (2010). ProstaCaid Induces G2/M Cell Cycle Arrest and Apoptosis in Human and Mouse Androgen–Dependent and –Independent Prostate Cancer Cells. Integrative Cancer Therapies 9 pp. 186-96.

http://ict.sagepub.com/content/9/2/186.abstract

 

[3] Wang, T. T., T. S., Hudson, T. C., et al. (2008). Differential effects of resveratrol on androgen responsive LNCaP human prostate cancer cells in vitro and in vivo. Carcinogenesis 29 pp. 2001-10.

http://carcin.oxfordjournals.org/cgi/content/short/29/10/2001

 

[4] Shenouda, N. S., C. Zhou, J. D. Browning, et al. (2004).  Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr Cancer 49 pp. 200-08.

http://www.ncbi.nlm.nih.gov/pubmed/15489213

 

[5] Lee, D. H., M. Szczepanski, Y. J. Lee (2008). Role of Bax in quercetininduced apoptosis in human prostate cancer cells. Biochem Pharmacol 75 pp. 2345-55

http://www.ncbi.nlm.nih.gov/pubmed/18455702

 

[6] Zhu, T., J. Guo, L. Collins, et al. (2007). Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells. Br J Cancer 96 pp. 583-90.

http://www.nature.com/bjc/journal/v96/n4/abs/6603595a.html

 

[7] Sliva D. (2003). Ganoderma lucidum (Reishi) in cancer treatment. Integr Cancer Ther 2 pp. 358-64.

http://www.ncbi.nlm.nih.gov/pubmed/14713328

 

[8] Hsieh, T.C., J. M. Wu (2001). Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom Trametes versicolor in androgen-dependent and androgen-insensitive

human prostate cancer cells. Int J Oncol 18 pp. 81-88.

http://www.ncbi.nlm.nih.gov/pubmed/11115542

 

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